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Descriptor English: Nogo Proteins
Descriptor Spanish: Proteínas Nogo
Descriptor proteínas Nogo
Entry term(s) NI-35-250
Nogo-A
inhibidor del crecimiento de las neuritas 35-350
proteína NI-220
proteína NI-250
proteína NI-35
proteína Nogo
proteína Nogo-66
proteína Nogo-A
proteína Nogo-B
proteína Nogo-C
proteína reticulon 4-B
proteína reticulon-4
Scope note: Proteínas de la mielina que se expresan como tres isoformas: Nogo-A, Nogo-B y Nogo-C. Estas comparten un dominio homólogo de reticulón (RHD) compuesto por dos dominios de membrana hidrófobos que flanquean una región hidrófila de 66 aminoácidos (Nogo-66). Una larga región transmembranaria permite conformaciones que abarcan toda la membrana o se pliegan en horquilla. Las proteínas Nogo inhiben el crecimiento de las NEURITAS y modulan las conexiones y la restricción de la PLASTICIDAD SINÁPTICA en el SISTEMA NERVIOSO CENTRAL del adulto. También regula la fasciculación, ramificación y extensión de las neuritas en el sistema nervioso en desarrollo.
Descriptor Portuguese: Proteínas Nogo
Descriptor French: Protéines Nogo
Entry term(s): NI 220 Protein
NI 250 Protein
NI 35 250
NI 35 Protein
NI-220 Protein
NI-250 Protein
NI-35 Protein
NI-35-250
Neurite Growth Inhibitor 35 350
Neurite Growth Inhibitor 35-350
Nogo 66 Protein
Nogo A Protein
Nogo B Protein
Nogo C Protein
Nogo Protein
Nogo-66 Protein
Nogo-A Protein
Nogo-B Protein
Nogo-C Protein
Reticulon 4 B Protein
Reticulon 4 Protein
Reticulon 4-B Protein
Reticulon-4 Protein
Tree number(s): D12.776.543.620.738
D12.776.631.580.738
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070798
Scope note: Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; NOGO PROTEIN was indexed under MYELIN PROTEINS 2000-2016
History Note: 2017 (2000)
DeCS ID: 56639
Unique ID: D000070798
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/11
Revision Date: 2016/07/11
Nogo Proteins - Preferred
Concept UI M0356759
Scope note Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Preferred term Nogo Proteins
Entry term(s) Nogo Protein
Reticulon 4 Protein
Reticulon-4 Protein
Nogo-C Protein - Narrower
Concept UI M0511040
Preferred term Nogo-C Protein
Entry term(s) Nogo C Protein
Neurite Growth Inhibitor 35-350 - Narrower
Concept UI M0511037
Preferred term Neurite Growth Inhibitor 35-350
Entry term(s) NI 35 250
NI-35-250
Neurite Growth Inhibitor 35 350
Nogo-A Protein - Narrower
Concept UI M0511038
Preferred term Nogo-A Protein
Entry term(s) NI 220 Protein
NI 250 Protein
NI-220 Protein
NI-250 Protein
Nogo A Protein
NI-35 Protein - Narrower
Concept UI M0511041
Preferred term NI-35 Protein
Entry term(s) NI 35 Protein
Nogo-B Protein - Narrower
Concept UI M0511039
Preferred term Nogo-B Protein
Entry term(s) Nogo B Protein
Reticulon 4 B Protein
Reticulon 4-B Protein
Nogo-66 Protein - Narrower
Concept UI M0441273
Preferred term Nogo-66 Protein
Entry term(s) Nogo 66 Protein



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